Sean Kitson,Ph.D. in Organic Chemistry and Molecular Toxicology from the University of Newcastle-upon-Tyne, UK. Thesis title: Mechanism of Carcinogenesis by Urethane. Received a Postgraduate Diploma in Medical Physics and MSc in Science from the Open University, UK. Investigator of Radiochemistry in the Department of Biocatalysis and Isotope Chemistry at Almac, Northern Ireland, UK. Before then Senior Radiochemist in the Custom Labelling Special Synthesis Team at GE Healthcare (formally Amersham plc). My contribution to radiochemistry was acknowledged by winning the 2006 Wiley - Journal of Labelled Compounds and Radiopharmaceuticals - Young Scientists Award for the elaborate radiosynthesis of the Parkinson’s drug apomorphine. Member of the Scientific Committee for the International Isotopes Society (IIS) UK group. Editor-in-Chief of Current Radiopharmaceuticals and editorial board member on several journals. The author of 40+ papers including reviews, editorials and commercial articles. My research interests includes radiolabelling of biomolecules including isotopic labelling of small molecules which can be utilised in A(D)ME studies. Other interests include neurology, diagnostic Imaging, medical physics, mathematics, hydroponics and aeroponics.
JLCR YOUNG SCIENTIST AWARD
My contribution to radiochemistry was acknowledged by winning the first Wiley JLCR Young Scientists Award in 2006 for the elaborate carbon-14 radiosynthesis of the Parkinson’s drug apomorphine.
PUBLICATIONS
Cheki M, Papie M, Mansi L, Kitson SL, Gali H. Preliminary Human Radiation Dose Estimates of PET Renal Agents, Para-18F-Fluorohippuric Acid and Ortho-124I-Iodohippuric Acid from Rat Biodistribution Data.
Curr Radiopharm. 2018; 11(1): 58-63. Reference Source
Mansi L, Kitson SL, Cuccurullo V, Ciarmiello A. Basic premises to molecular imaging
and radionuclide therapy. J Diagn Imaging Ther. 2014; 1(1): 137-156.CrossRef
Sperandeo A, Ficola U, Quartuccio N,
Kitson SL, Mansi L, Cistaro A. Automated synthesis of
[18F]fluorocholine using a modified GE TracerLab module. J Diagn
Imaging Therapy. 2014; 1(1): 49-58. CrossRef
Kitson SL. Moody TS, Watters W. Modern Developments
in Isotopic Labelling.OutsourcedPharma. 2014; Sept 2. Reference
Source
Kitson SL. Positron Emission Tomography
Neuro-Imaging. Neuro Open J. 2014; 1(1): 1-4. CrossRef
Kitson SL. Application of Radionuclides and
Antibody-Drug Conjugates. Cancer Stud Mol Med Open J. 2014; 1(1):
1-7. CrossRef
Kitson SL, Moody TS, Speed D, Watters W. Making Hot
ADCs. ADC Review / Journal of Antibody-drug Conjugates. 2014; March
7. CrossRef
Kitson SL. Seeing through the MIST. Manufacturing
Chemist. 2012; Sept 24. Reference
Source
Bell SJ, McIntyre S, Garcia CF, Kitson SL, Therkelsen F, Andersen SM, et
al. Development of an Efficient and Practical Route for the Multi-kilogram
Manufacture of Ethyl 5-Cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
and Ethyl 6-Chloro-5-cyano-2-methylnicotinate, Key Intermediates in the
Preparation of P2Y12 Antagonists. Org Process Res. Dev. 2012; 16(5):
819-823. CrossRef
Kitson SL. Keeping Tags on Biomolecules. ManufacturingChemist.
2012; April: 36-37. Reference
Source
Kitson SL. Editorial Review of 2012. Curr
Radiopharm. 2012; 5(1): 1-4. Reference Source
Leman L, Kitson SL, Brown RT, Cairns J, Watters W, McMordie A, et al.
Synthesis of isotopically labelled [14C]ZT-1 (Debio-9902), [d3]ZT-1 and
(−)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors. J
Label Compd Radiopharm. 2011; 54: 720-730. CrossRef
Kitson SL, Jones S, Watters W, Chan F, Madge D.
Carbon-14 radiosynthesis of
4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-[4-14C]quinolin-2(1H)-one
(XEN-D0401), A novel BK channel activator. J Label Compd Radiopharm. 2010;
53: 140-146. CrossRef
Kitson SL. Accelerated Radiochemistry,Pharmaceutical
Manufacturing and Packing Sourcer. 2010; Spring: 68-70. Reference
Source
Kitson SL, Cuccurullo V, Ciarmiello A, Salvo D,
Mansi L. Clinical Applications of Positron Emission Tomography (PET)
Imaging in Medicine: Oncology, Brain Diseases and Cardiology. Curr
Radiopharm. 2009; 2, 224-253. CrossRef
Duatti A, Kitson SL, Mansi L. Is there only F-18 (and on-site
cyclotrons) in the future of Nuclear Medicine? Curr Radiopharm. 2009;
2, 222-223. Reference
Source
Kitson SL. Editorial (Letter from the
Editor-in-Chief of Current Radiopharmaceuticals).Curr Radiopharm. 2009;
2(1): 1. Reference
Source
Kitson SL. Mechanism of the Bischler-Napieralski
exocyclic and endocyclic dehydration products in the radiosynthesis of (R)-(-)-[6a-14C]Apomorphine.
J Label Compd Radiopharm. 2007; 50: 290-294. CrossRef
Woolley GT, Kitson SL, Reid RG. Synthesis of the
Myoview Ligand [bisphosphinoethane-1,2-14C]tetrofosmin. J Label Compd
Radiopharm. 2007; 50: 468-470. CrossRef
Shemilt G, Newby M, Kitson SL. The Design of
Radiolabelled Carbon-14 Polymers. J Label Compd Radiopharm. 2007;
50: 515-518. CrossRef
Kitson SL. Amersham Radiochemistry to GE
Healthcare. J Label Compd Radiopharm. 2007; 50: 737-745. CrossRef
Kitson SL, Knagg E. Application of the
Bischler-Napieralski-Pschorr Radiosynthesis of (R)-(-)-[6a-14C]
Apomorphine, A non-selective D1/D2 Dopamine Receptor Agonist. J Label
Compd Radiopharm. 2006; 49: 517-531. CrossRef
Kitson SL. (2004), ‘Design and Application of
Stable or Radolabelled Carbamates’, Synthesis and Applications of
Isotopically Labelled Compounds, Edited by D C Dean, C N Filer and K E
McCarthy. John Wiley and Sons Ltd,8, pp. 317-320.
Kitson SL. Squarate Molecular Metaphors: A Strategy
for Drug Design,’ personal communication, 1, 1-140 (2001).
Kitson SL. Molecular Metaphor Drugs: A New Approach
to Rational Drug Design’, personal communication, 2, 1-263 (2001).
Bleasdale C, Golding BT, Kitson SL.
Preparation of Ethenyl and Oxiranol Carbamates and their
[2-2H2]-Derivatives using Selenium Chemistry; Thermolysis of Oxiranol
Carbamate and Reaction with Adenosine. Chem. Letts. 1994;4:
291-296. Reference
Source
Kitson SL. The Mechanism of Carcinogenesis by Urethane. PhD Thesis, University of Newcastle upon Tyne. 1993. ISNI 0000 0001 3600 6154. Reference Source
Khaled A, Bleasdale C, Golding BT,
Kitson SL. New Applications of the Protecting Group
Di-(4-methoxyphenyl)methyl: N-Protection of Urethanes and Uridines,
and Efficient Removal by either Ceric Ammonium Nitrite/Silica or
2,3-Dichloro-5,6-Dicyanoquinone.Tetrahedron Letts. 1992; 33:
4807-4810. Reference
Source
CONFERENCE SPEAKER
Cancer Drug Discovery & Preclinical Development conference on 17-18 September, 2014 in London. ‘Antibody-Drug Conjugates.’
4th Annual Biologics Symposium, London, UK, February 25-26, 2014. ‘Enabling Technologies – Carbon-14 Labelled ADCs and Peptides.’
BioTrinity 2012 – European Bio-partnering and Investment Conference, Newbury Racecourse, UK, April 24-26. ‘Workshop on Carbon-14 Labelled Peptides - Solid Phase Peptide Synthesis, Bio-tinylation and PEGylation.
SP2 Peptide Conference 2012, Chilford Hall Conference Centre, Cambridge, April 17-18. ‘Carbon-14 Labelled Peptide APIs:Solid Phase Peptide Synthesis, Biotinylation & PEGylation.’
7th International Conference on Isotopes -Moscow, Russia 2011, World Trade Center, September 5-8. ‘Synthesis of isotopically labelled [14C]ZT-1,[d3]ZT-1 & (-)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors.
The Synthesis of BioActive Molecules VI Symposium 2011, University College Cork, July 29. ‘Synthetic Strategies for Carbon-14 Labelling of Drug Molecules.’
International Isotope Society, 18th Annual UK Group Symposium on Synthesis and Applications of Labelled Compounds2009, Hinxton, Cambridge 12 November. ‘Carbon-14 radiosynthesis of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-[4-14C]quinolin-2(1H)-one (XEN-D0401), A novel BK channel activator.’
9th International Symposium on the Synthesis and Application of Isotopes and Isotopically Labelled Compounds 2006, Edinburgh 16-20 July. ‘The Radiochemical Synthesis of (R)-(-)-[6a-14C]Apomorphine.’
Newcastle-Kyoto Chemical Biology Symposium 2006, University of Newcastle December 1-4. ‘The Radiochemical Synthesis of (R)-(-)-[6a-14C]Apomorphine.’
CONFERENCE SCIENTIFIC POSTERS
Kitson SL. Carbon-14 Labelled Peptide APIs: Solid Phase Peptide Synthesis, Biotinylation & PEGylation, Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds. J Label Compd Radiopharm. 2011; 55: 125-134. [Reference Source]
Kitson SL, et al. Carbon-14 Labelling of Antibody Drug Conjugates (ADCs) (2011), 19thinternational isotope society (UK group) symposium: synthesis & applications of labelled compounds. J Label Compd Radiopharm. 2010; 54: 387-398. [Reference Source]
Kitson SL. Hydrolysis of [14C]-Nitrile using Nitrilase (NIT) Biocatalysts, Abstracts of the 18thinternational isotope society (UK group) symposium: synthesis & applications of labelled compounds. J Label Compd Radiopharm. 2009; 53: 521-534. [Reference Source]
Kitson SL. Synthesis of the Ligand [bisphosphinoethane-1,2-14C]tetrofosmin for MyoviewTMdevelopment, Abstracts of the 9th International Symposium on the Synthesis and Application of Isotopes and Isotopically Labelled Compounds 2006, Edinburgh 16-20 July, UK. 248.
Kitson SL. Application of the Bischler-Napieralski-Pschorr Radiosynthesis of (R)-(-)-[6a-14C]Apomorphine, A D1/D2Dopamine Receptor Agonist, Abstracts of the 9th International Symposium on the Synthesis and Application of Isotopes and Isotopically Labelled Compounds 2006, Edinburgh 16-20 July, UK. 25.
Kitson SL. ‘Bischler-Napieralski-Pschorr Radiosynthesis of (R)-(-)-[6a-14C]Apomorphine’, Abstracts of the 15th International Isotope Society (UK group) Symposium 2006. J Label Compd Radiopharm; 49, pp. 411-412. [Reference Source]
Kitson SL. (2004), ‘Application of Stable or Radiolabelled Carbamates’, 13th IIS UK symposium Hinxton, UK, J Label Compd Radiopharm, 47, pp. 320 (Abstract) [Reference Source]
Kitson SL. (2003), ‘Application of Stable or Radiolabelled Carbamates’, 8th International Symposium on the Synthesis and Application of Isotopes and Isotopically Labelled Compounds, Boston, USA. Abstract: (2004), 13th IIS (UK group) symposium. J Label Compd Radiopharm, 47: 299–334. [Reference Source]
EDITORIAL
2014 - Present: Editorial Director - Journal of Diagnostic Imaging in Therapy. [JDIT]
2007 - Present: Editor-in-Chief of Current Radiopharmaceuticals. [CRP]
2014 - Present: Associate Editor - The Open Chemistry Journal.[TOCJ]
2007 - 2014: Editor-in-Chief of Current Process Chemistry.
Reviewer for the Journal of Labelled Compounds and Radiopharmaceuticals.
2009 - Present: International Isotopes Society (IIS) scientific committee member (UK group).